3,5-Dimethoxyphenol → 3-(3,5-Difluorophenyl)-4,6-dimethoxy-1-benzofuran

HRID 76833

反応式

HRID 76833 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([OH:11])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.Br[CH2:13][C:14]([C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=1)=O>>[F:23][C:18]1[CH:17]=[C:16]([C:14]2[C:6]3[C:7]([O:9][CH3:10])=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=3[O:11][CH:13]=2)[CH:21]=[C:20]([F:22])[CH:19]=1

参加物

3

反応物 2

HCID 103833,5-DimethoxyphenolHCID 27783312-Bromo-1-(3,5-difluorophenyl)ethanone

生成物 1

HCID 545909623-(3,5-Difluorophenyl)-4,6-dimethoxy-1-benzofuran収率 68%

実験手順

This compound was prepared using Method B from 3,5-dimethoxyphenol and 2-bromo-1-(3,5-difluorophenyl)ethanone: Yield 68% following procedures B.2 and B.3; m.p. 102-103° C.; IR 2937, 1591, 1501, 1444, 1354, 1217, 1113 cm−1; 1H-NMR (300 MHz, δ ppm, CDCl3) 7.49 (s, 1H), 7.20-7.11 (m, 2H), 6.75 (tt, J=9.0 Hz, 2.3 Hz, 1H), 6.66 (d, J=1.9 Hz, 1H), 6.36 (d, J=1.9 Hz, 1H), 3.84 (s, 3H), 3.82 (s, 3H); 13C-NMR (75 MHz, δ ppm, CDCl3) 162.8 (dd, J=246.5 Hz, 13.3 Hz), 159.7, 158.2, 154.6, 140.7, 135.8 (t, J=10.6 Hz), 121.5, 112.2 (dd, J=8.1 Hz, 17.4 Hz), 109.2, 102.4 (t, J=25.5 Hz), 95.0, 88.6, 55.9, 55.5.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-e885fc8638c9435783a4fa3120baee5e
出典データセット
uspto-grants-2014_09
特許番号
US08835659B2

関連ノート

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