Methanol → Methyl 2-(3-fluoro-4-methoxyphenyl)acetate
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].OS(O)(=O)=O.[CH3:19]O>>[CH3:19][O:12][C:11](=[O:13])[CH2:10][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=1参加物
4
実験手順
(3-Fluoro-4-methoxyphenyl)acetic acid (5.0 g, 27.1 mmol) is dissolved in MeOH (100 mL). To it is added concentrated H2SO4 (5 mL) and the solution is warmed to reflux for 2 h. At that point, the solution is evaporated to dryness and taken up in EtOAc. The solution is washed with saturated aqueous NaHCO3, dried (Na2SO4) and evaporated to give (3-fluoro-4-methoxyphenyl)acetic acid methyl ester (cas#588-14-7) as a yellow oil. MS (ESI) m/z 199.3 (M+H).
後処理
- temperaturethe solution is warmed
- temperatureto reflux for 2 h
- customAt that point, the solution is evaporated to dryness
- washThe solution is washed with saturated aqueous NaHCO3
- dry with materialdried (Na2SO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-e13010eba7f949f8b5c492ff8efc8691
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08835646B2
反応ノート
読み込み中…