Ethanol → Ethyl 2-(3-fluorophenyl)acetate

HRID 76966

反応式

HRID 76966 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[CH2:17](O)[CH3:18]>>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:17][CH3:18])=[O:10])[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 676173-Fluorophenylacetic acid

生成物 1

HCID 11735538Ethyl 2-(3-fluorophenyl)acetate収率 85%

実験手順

To a solution of 3-fluorophenyl acetic acid (10.0 g, 64.9 mmol) in ethanol (300 mL), is added a catalytic amount of H2SO4 (98%, 1 mL) and the mixture reacted for 12 hours at 100° C. (LC-MS monitoring: complete conversion). The solvent is evaporated and the residue is partitioned between EtOAc and water; the organic layer is separated and dried over Na2SO4 in order to obtain 10.1 g of (I8) as a white solid (85% yield).

後処理

  1. customthe mixture reacted for 12 hours at 100° C. (LC-MS monitoring: complete conversion)
  2. customThe solvent is evaporated
  3. customthe residue is partitioned between EtOAc and water
  4. customthe organic layer is separated
  5. dry with materialdried over Na2SO4 in order

出典と根拠

ORDレコード
ord-38049ee9739249dfa2ee123b242c4d2b
出典データセット
uspto-grants-2014_09
特許番号
US08835682B2

関連ノート

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