関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Oxazolidinone | HCID 73949 | — |
| 反応物 | 4-(2-Bromo-1,3-thiazol-4-yl)benzonitrile | HCID 112623600 | — |
| 試薬 | Cesium carbonate | HCID 10796 | — |
| 触媒 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 触媒 | Palladium (II) acetate | HCID 4144353 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-[2-(2-Oxo-1,3-oxazolidin-3-yl)-1,3-thiazol-4-yl]benzonitrile | HCID 25028715 | 0% |
反応手順
4-(2-bromothiazol-4-yl)benzonitrile (100 mg, 0.38 mmol), 2-Oxazolidinone (49.3 mg, 0.57 mmol), diacetoxypalladium (5.93 mg, 0.03 mmol), cesium carbonate (369 mg, 1.13 mmol), water (10 µl) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (21.82 mg, 0.04 mmol) were suspended in dioxane (2 mL), thoroughly degassed and sealed into a microwave tube and stirred at RT for 20 mins. The reaction was then heated to 150 °C for 10 minutes in the microwave reactor and cooled to RT. Load of rubbish... ABANDONED
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-b8e52e6f1bc8459e8364a7285d41ce7c |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
