化工社化工社 化学情報印刷レポート · 研究参考用
Water → N-(2-Amino-5-methoxy-phenyl)-5-bromo-2-fluoro-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 5-Bromo-2-fluorobenzoic acid | HCID 2736315 | — |
| 反応物 | 4-Methoxybenzene-1,2-diamine dihydrochloride | HCID 3085161 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(2-Amino-5-methoxy-phenyl)-5-bromo-2-fluoro-benzamide | HCID 63257662 | 62.4% |
反応手順
Method 6—Step a A mixture of 5-Bromo-2-fluoro-benzoic acid (1.50 g, 6.85 mmol), 4-methoxy-benzene-1,2-diamine dihydrochloride (1.77 g, 8.49 mmol), HATU (2.73 g, 7.19 mmol) and TEA (2.88 mL, 20.76 mmol) in dichloromethane (20 mL) and DMF (5 mL) was stirred at room temperature overnight, then water was added (50 mL), mixture was stirred for 2 h and left standing at room temperature overnight. The precipitate obtained was filtered off and dried to afford 1.45 g of the title compound (50%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835648B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-d73d945322a94c8a9a3b8a50b768d317 |
| 出典メモ | uspto-grants-2014_09 |