HCID 66977622、化合物 → HCID 178479749、化合物

HRID 77084ノート

反応式

HRID 77084 の反応式
C(OC([N:8]1[C:12]2[CH:13]=[CH:14][C:15]([Cl:17])=[CH:16][C:11]=2[N:10]=[C:9]1[C:18]1[CH:23]=[C:22]([N:24]2[CH2:29][CH2:28][CH:27]([C:30]([O:32]CC)=[O:31])[CH2:26][CH2:25]2)[CH:21]=[CH:20][C:19]=1[F:35])=O)(C)(C)C>Cl>[ClH:17].[Cl:17][C:15]1[CH:14]=[CH:13][C:12]2[NH:8][C:9]([C:18]3[CH:23]=[C:22]([N:24]4[CH2:25][CH2:26][CH:27]([C:30]([OH:32])=[O:31])[CH2:28][CH2:29]4)[CH:21]=[CH:20][C:19]=3[F:35])=[N:10][C:11]=2[CH:16]=1

参加物

3

反応物 1

HCID 66977622HCID 66977622、化合物

生成物 1

HCID 178479749HCID 178479749、化合物収率 138.1%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
120 °C

実験手順

Method 10—Step b A mixture of 5-Chloro-2-[5-(4-ethoxycarbonyl-piperidin-1-yl)-2-fluoro-phenyl]-benzoimidazole-1-carboxylic acid tert-butyl ester (0.30 g, 0.60 mmol) in 6N HCl (10 mL) was heated in microwave at 120° C. for 15 minutes, two cycles were needed. Solvent was removed under vacuum, then the solid was filtered and washed with diethyl ether and dried to obtain 0.17 g of the title compound (70%).

後処理

  1. customSolvent was removed under vacuum
  2. filtrationthe solid was filtered
  3. washwashed with diethyl ether
  4. customdried

出典と根拠

ORDレコード
ord-f584e951ef744dbd88437a0f511dff0a
出典データセット
uspto-grants-2014_09
特許番号
US08835648B2

反応ノート

読み込み中…