1,4-Dioxane hydrochloride → (R)-2-Methoxy-1-phenylethanamine hydrochloride

HRID 773

反応式

HRID 773 の反応式
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH3:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH3:25][O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

3

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 54257308N-t-butoxycarbonyl-(R)-alpha-methoxymethylbenzylamine

生成物 1

HCID 66589172(R)-2-Methoxy-1-phenylethanamine hydrochloride

実験手順

60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. addition30 ml of ether were added to the residue
  3. concentrationthis was further concentrated

出典と根拠

ORDレコード
ord-3d062dc2d8ab4e1391656e4f536498a8
出典データセット
uspto-grants-1998_03
特許番号
US05723165

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