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Methanol → D-Leucine, methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | tert-Butoxycarbonyl-D-leucine | HCID 637604 | — |
| 生成物 | D-Leucine, methyl ester | HCID 89967 | — |
反応手順
To a solution of (R)-2-tert-butoxycarbonylamino-4-methyl-pentanoic acid (2 g, 8.7 mmol) in methanol (20 mL) is added thionyl chloride (2.59 g, 21.7 mmol). The reaction mixture is refluxed for 2 h. The reaction mixture is cooled to room temperature and concentrated in vacuo. The crude product is carried on without any further purification. 1H NMR (400 MHz, MeOD): δ 1.00 (q, 6H, J=3 Hz), 1.7-1.9 (m, 3H, J=7.7 Hz), 3.85 (s, 3H), 4.0 (t, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841291B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-14e00b9ebc264711ae9b0cd93e1f31b4 |
| 出典メモ | uspto-grants-2014_09 |