Hydrochloric Acid → HCID 86653280、化合物
反応式
C([NH:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][C:11]([S:15]([N:18]([CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])[CH:19]([CH:24]([CH3:26])[CH3:25])[C:20]([NH:22][OH:23])=[O:21])(=[O:17])=[O:16])=[CH:12]2)=[CH:7][CH:6]=1)(=O)C.Cl>CO>[NH2:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][C:11]([S:15]([N:18]([CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])[CH:19]([CH:24]([CH3:25])[CH3:26])[C:20]([NH:22][OH:23])=[O:21])(=[O:17])=[O:16])=[CH:12]2)=[CH:7][CH:6]=1参加物
4
実験手順
2-[(7-Acetylamino-naphthalene-2-sulfonyl)-(3-methyl-butyl)-amino]-N-hydroxy-3-methyl-butyramide (100 mg, 0.22 mmol) (example 61), 3 N hydrochloric acid (2 mL) and methanol (5 mL) are combined and stirred at reflux for 4 hours. The mixture is stirred at room for 60 hours. The solvent is partially removed in vacuo and a red precipitate forms. This precipitate is collected by filtration and air dried. LCMS (m/z): 408.2 (M+1), 406.3 (M−1).