2-Naphthalenesulfonyl chloride → 2,2-Dimethyl-4-(naphthalene-2-sulfonyl)-thiomorpholine-3-carboxylic acid
反応式
[CH3:1][C:2]1([CH3:11])[S:7][CH2:6][CH2:5][NH:4][C@H:3]1[C:8]([OH:10])=[O:9].[CH:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[S:22](Cl)(=[O:24])=[O:23]>>[CH3:1][C:2]1([CH3:11])[S:7][CH2:6][CH2:5][N:4]([S:22]([C:13]2[CH:14]=[CH:15][C:16]3[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:12]=2)(=[O:24])=[O:23])[CH:3]1[C:8]([OH:10])=[O:9]参加物
3
実験手順
Following typical sulfonylation conditions and method L, the title compound is prepared from (S)-2,2-dimethyl-thiomorpholine-3-carboxylic acid and naphthalene-2-sulfonyl chloride. LCMS (m/z): 381.2 (M+1), 379.3 (M−1), CHN: Calc CHN: 53.66, 5.30, 7.36. Found CHN: 593.51, 5.20, 7.07.
出典と根拠
- ORDレコード
- ord-d15c03bb3ed448518e68877c302ddfdf
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841291B2