2-Amino-4,6-dimethyl pyrimidine → HCID 178425977、化合物

HRID 77344

反応式

HRID 77344 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([NH2:9])[N:3]=1.[NH2:10]O.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[C:15]([CH3:20])[C:14]=1[S:21]([O-:24])(=[O:23])=[O:22]>C(Cl)Cl>[CH3:20][C:15]1[CH:16]=[C:17]([CH3:19])[CH:18]=[C:13]([CH3:12])[C:14]=1[S:21]([O-:24])(=[O:23])=[O:22].[NH2:10][N:3]1[C:2]([CH3:1])=[CH:7][C:6]([CH3:8])=[N:5][C:4]1=[NH2+:9]

参加物

4

反応物 2

HCID 130212-Amino-4,6-dimethyl pyrimidineHCID 19699281hydroxylamine 2,4,6-Trimethyl-benzenesulfonate

生成物 1

HCID 178425977HCID 178425977、化合物収率 62%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

To a solution of 4,6-Dimethyl-pyrimidin-2-ylamine (25 g, 200 mmol) in 400 mL of CH2Cl2 was added dropwise a solution of hydroxylamine-2,4,6-Trimethyl-benzenesulfonate (105 g, 488 mmol) in 300 mL of CH2Cl2 at 0° C., and the mixture was stirred at 0° C. for 1 hand filtered. The solid collected was washed with CH2Cl2 (100 mL) to give 1-Amino-4,6-dimethyl-1H-pyrimidin-2-ylidene-ammonium 2,4,6-Trimethyl-benzenesulfonate (40 g, yield: 62%).

後処理

  1. filtrationfiltered
  2. customThe solid collected
  3. washwas washed with CH2Cl2 (100 mL)

出典と根拠

ORDレコード
ord-add5d4ed43ad44c2b6d3159b4aec0f84
出典データセット
uspto-grants-2014_09
特許番号
US08841297B2

関連ノート

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