Triethylamine → 2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(3-hydroxy-2,2-dimethylpropyl)-5-nitroisonicotinamide

HRID 77395

反応式

[N:1]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[N:4]([C:10]1[CH:11]=[C:12]([C:16]([N+:19]([O-:21])=[O:20])=[CH:17][N:18]=1)[C:13]([OH:15])=O)[CH2:3][CH2:2]2.[NH2:22][CH2:23][C:24]([CH3:28])([CH3:27])[CH2:25][OH:26].C(N(CC)CC)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C>[N:1]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[N:4]([C:10]1[CH:11]=[C:12]([C:16]([N+:19]([O-:21])=[O:20])=[CH:17][N:18]=1)[C:13]([NH:22][CH2:23][C:24]([CH3:28])([CH3:27])[CH2:25][OH:26])=[O:15])[CH2:3][CH2:2]2

参加物

実験手順

To a solution of 2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-5-nitroisonicotinic acid (Intermediate 29A) (2.0 g, 6.8 mmol) in DMF (25 mL) was added 3-amino-2,2-dimethylpropan-1-ol (0.85 g, 8.2 mmol), triethylamine (1 g, 10.3 mmol) and HATU (3.16, 10.3 mmol) under nitrogen, reaction then stirred overnight. The reaction mixture was concentrated and purified by HPLC to afford 2-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-N-(3-hydroxy-2,2-dimethylpropyl)-5-nitroisonicotinamide.

後処理

customreaction
concentrationThe reaction mixture was concentrated
custompurified by HPLC

出典と根拠

ORDレコード: ord-540952facf774d819c19fd0688b019ec
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08841289B2

反応式

参加物

反応物 4

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

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