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Ethyl 2-azido-3-(5-bromothiophen-2-yl)acrylate → ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 2-azido-3-(5-bromothiophen-2-yl)acrylate | HCID 73166977 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate | HCID 13164349 | 82% |
反応手順
Acrylate 60 (3.81 g, 12.6 mmol) in o-xylene was refluxed for 20 min. After removing the o-xylene, the crude product was purified by column chromatography (EtOAc/Hexane: 1/10) to give carboxylate 61 (2.83 g, 82%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841305B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-5f4536bbbabf40fe8757e28a2bdfa0eb |
| 出典メモ | uspto-grants-2014_09 |