Benzoyl Peroxide → NCS Chloride
反応式
FC1C=CC=C(C)N=1.[CH2:9]1[C:14](=[O:15])[N:13]([Cl:16])[C:11](=[O:12])[CH2:10]1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C1C=CC=CC=1>[CH2:9]1[C:14](=[O:15])[N:13]([Cl:16])[C:11](=[O:12])[CH2:10]1.[Cl-:16]参加物
5
実験手順
2-Fluoro-6-methylpyridine (1.11 g, 10 mmol), NCS (2.0 g, 15 mmol), and catalytic benzoyl peroxide were dissolved in benzene and heated to reflux overnight. The reaction was concentrated and diluted with water and EtOAc. The organic layer was washed with saturated aq. NaHCO3, dried, filtered, and concentrated. The residue was purified on silica gel to give the desired product.
後処理
- temperatureheated
- temperatureto reflux overnight
- concentrationThe reaction was concentrated
- additiondiluted with water and EtOAc
- washThe organic layer was washed with saturated aq. NaHCO3
- customdried
- filtrationfiltered
- concentrationconcentrated
- customThe residue was purified on silica gel
出典と根拠
- ORDレコード
- ord-76c2d06d270544abb8267483dadb4bcd
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841295B2
反応ノート
読み込み中…