1,4-Dioxane hydrochloride → (1R)-2-ethoxy-1-phenylethan-1-amine hydrochloride
反応式
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH2:25][CH3:26])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH2:25]([O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:26]参加物
3
実験手順
12.5 ml of 4N-HCl/dioxane solution were added to 0.66 g (2.5 mmols) of N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, 30 ml of ether was added to the residue, and this was further concentrated to obtain (R)-α-ethoxymethylbenzylamine hydrochloride at a quantitative yield.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure, 30 ml of ether
- additionwas added to the residue
- concentrationthis was further concentrated
出典と根拠
- ORDレコード
- ord-ae03dc6af35144969588f144b56bba80
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723165
反応ノート
読み込み中…