1,4-Dioxane hydrochloride → (1R)-2-ethoxy-1-phenylethan-1-amine hydrochloride

HRID 775

反応式

HRID 775 の反応式
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH2:25][CH3:26])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH2:25]([O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:26]

参加物

3

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 53739234N-t-butoxycarbonyl-(R)-alpha-ethoxymethylbenzylamine

生成物 1

HCID 70183214(1R)-2-ethoxy-1-phenylethan-1-amine hydrochloride

実験手順

12.5 ml of 4N-HCl/dioxane solution were added to 0.66 g (2.5 mmols) of N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, 30 ml of ether was added to the residue, and this was further concentrated to obtain (R)-α-ethoxymethylbenzylamine hydrochloride at a quantitative yield.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure, 30 ml of ether
  2. additionwas added to the residue
  3. concentrationthis was further concentrated

出典と根拠

ORDレコード
ord-ae03dc6af35144969588f144b56bba80
出典データセット
uspto-grants-1998_03
特許番号
US05723165

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