化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3,5-Diamino-6-chloro-pyrazine acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate | HCID 73827 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3,5-Diamino-6-chloro-pyrazine acid | HCID 6452119 | — |
反応手順
A mixture of methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (100 g; 494 mmol), methanol (1 L) and NaOH (6 mol/L in water; 240 mL; 1.44 mol) is refluxed for 3 h. The mixture is allowed to cool to room temperature and then neutralised by addition of hydrochloric acid (6 M in water; ca. 120 mL). Water (200 mL) is added. The precipitate formed is collected by filtration while applying suction, washed with water and dried at 60° C. Yield: 99.6 g (107% of theory).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841309B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-1eeb9b6e8bfc462294df91890cc93ba8 |
| 出典メモ | uspto-grants-2014_09 |