Diethyl Ether → 2-Amino-5-bromo-4-methoxybenzonitrile

HRID 77522ノート

反応式

HRID 77522 の反応式
[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Br:12]Br.C(OCC)C>O1CCOCC1>[NH2:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([Br:12])=[CH:6][C:3]=1[C:4]#[N:5]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 37231282-Amino-4-methoxybenzonitrile

生成物 1

HCID 574230422-Amino-5-bromo-4-methoxybenzonitrile収率 81%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
0 °C

実験手順

2-Amino-4-methoxybenzonitrile (4.47 g, 30.2 mmol) is dissolved in 70 ml of dioxane and treated at 0° C. with bromine (1.71 ml, 33.2 mmol). It is subsequently stirred at 0° C. for one hour. After addition of diethyl ether, the resulting crystals are filtered off with suction. The desired product is obtained in 81% yield (5.52 g).

後処理

  1. filtrationthe resulting crystals are filtered off with suction

出典と根拠

ORDレコード
ord-62bed51aad364d0ca402331d29457e73
出典データセット
uspto-grants-2014_09
特許番号
US08841311B2

反応ノート

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