関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Aminophenol | HCID 5801 | — |
| 反応物 | Vanillic Acid | HCID 8468 | — |
| 溶媒 | Trimethyl(phosphooxy)silane | HCID 16133246 | — |
| 生成物 | 4-(Benzo[d]oxazol-2-yl)-2-methoxyphenol | HCID 135530812 | — |
反応手順
4-hydroxy-3-methoxybenzoic acid (25 g, 149 mmol) and 2-amino phenol (16.2 g, 149 mmol) were combined in a round bottom flask. Trimethylsilyl polyphosphate (80 mL) was added neat. The mixture was heated at 180° C. for 30 min. The mixture is poured over ice and allowed to stir overnight. The suspension was filtered to afford 4-(1,3-benzoxazol-2-yl)-2-methoxyphenol as a pale green solid. MS (ESI) 242 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07087601B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-b5491a6e17264b91ba9e8509c39cb5aa |
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| 出典メモ | uspto-grants-2006_08 |
|---|
