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Water → 5-(1,3-Benzoxazol-2-yl)-2-hydroxy benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Boron tribromide | HCID 25134 | — |
| 反応物 | 5-(1,3-Benzoxazol-2-yl)-2-methoxy benzonitrile | HCID 21990983 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-(1,3-Benzoxazol-2-yl)-2-hydroxy benzonitrile | HCID 135752521 | — |
反応手順
To a solution of 5-(1,3-benzoxazol-2-yl)-2-methoxy benzonitrile (270 mg, 1.1 mmol) in CH2Cl2 (5 mL) at 0° C., was added BBr3 (1.0M solution in CH2Cl2, 430 μL, 4.4 mmol) dropwise. The reaction was stirred at it for 4 h. EtOAc (150 mL) was added, as well as H2O (30 mL). The organic layer was washed with brine (2×20 mL), dried (MgSO4), concentrated and the crude product was recrystallized in EtOAc to afford 5-(1,3-benzoxazol-2-yl)-2-hydroxy benzonitrile. MS (ESI) 237 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087601B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-d520da0a211748ddab0429d699c7af31 |
| 出典メモ | uspto-grants-2006_08 |