Hydrochloric Acid → 5-Chloro-2-(3-methoxy-4-pyridin-2-yl phenyl)-1,3-benzoxazole hydrochloride

HRID 7773ノート

反応式

HRID 7773 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=4)=[C:12]([O:22][CH3:23])[CH:11]=3)=[N:7][C:6]=2[CH:24]=1.Cl>ClCCl.C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=4)=[C:12]([O:22][CH3:23])[CH:11]=3)=[N:7][C:6]=2[CH:24]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 102866725-Chloro-2-(3-methoxy-4-pyridin-2-ylphenyl)-1,3-benzoxazole

生成物 1

HCID 219909475-Chloro-2-(3-methoxy-4-pyridin-2-yl phenyl)-1,3-benzoxazole hydrochloride

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒

実験手順

5-Chloro-2-(3-methoxy-4-pyridin-2-ylphenyl)-1,3-benzoxazole (26 mg) was stirred in dichloromethane. 1.0M HCl in diethyl ether (0.95 mL) was added and allowed reaction mixture to stir for 30 minutes. Concentration of reaction mixture in vacuo gave the desired compound, 5-chloro-2-(3-methoxy-4-pyridin-2-yl phenyl)-1,3-benzoxazole hydrochloride, as a pink solid. 1H NMR (CD3OD, 300 MHz) δ 8.88–7.46 (m, 10H), 4.11 (s, 3H). MS (ESI) 337 (M+H)+.

後処理

  1. customreaction mixture
  2. customConcentration of reaction mixture in vacuo

出典と根拠

ORDレコード
ord-d51a620251244c06bff5500e31331620
出典データセット
uspto-grants-2006_08
特許番号
US07087601B2

反応ノート

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