Triethylamine → 5-Iodo-6-methylpyridin-3-yl-3-(trifluoromethyl)benzamide

HRID 77733ノート

反応式

HRID 77733 の反応式
[I:1][C:2]1[CH:3]=[C:4](N)[CH:5]=[N:6][C:7]=1[CH3:8].C([N:12](CC)CC)C.[F:17][C:18]([F:29])([F:28])[C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][CH:27]=1)[C:22](Cl)=[O:23]>C(Cl)Cl>[I:1][C:2]1[CH:3]=[C:4]([C:20]2[C:19]([C:18]([F:29])([F:28])[F:17])=[CH:27][CH:26]=[CH:25][C:21]=2[C:22]([NH2:12])=[O:23])[CH:5]=[N:6][C:7]=1[CH3:8]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 591982915-Iodo-6-methylpyridin-3-amine

生成物 1

HCID 866991415-Iodo-6-methylpyridin-3-yl-3-(trifluoromethyl)benzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of 5-iodo-6-methylpyridin-3-amine (125 mg, 0.534 mmol) in methylene chloride (1 mL) was added triethylamine (0.087 mL, 0.627 mmol) and cooled at 0° C. Into the reaction was added 3-(trifluoromethyl)benzoyl chloride (0.0812 mL, 0.538 mmol) dropwise and stirred at 0° C. for 45 minutes and at 25° C. for 16 hours. The reaction was extracted with EtOAc and the organic extracts were washed with water saturated Na2CO3, saturated NaCl, dried (MgSO4) and stripped in vacuo. The product was used in the next reaction without purification.

後処理

  1. extractionThe reaction was extracted with EtOAc
  2. washthe organic extracts were washed with water saturated Na2CO3, saturated NaCl
  3. dry with materialdried (MgSO4)
  4. customThe product was used in the next reaction without purification

出典と根拠

ORDレコード
ord-12d4c92d7f6b4c978975e1ea8978481d
出典データセット
uspto-grants-2014_09
特許番号
US08841318B2

反応ノート

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