Acetic Acid → trans-4-Bromo-beta-nitrostyrene

HRID 78241

反応式

HRID 78241 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[N+:10]([CH3:13])([O-:12])=[O:11].C([O-])(=O)C.[NH4+].C(O)(=O)C>O>[Br:1][C:2]1[CH:9]=[CH:8][C:5](/[CH:6]=[CH:13]/[N+:10]([O-:12])=[O:11])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 6375NitromethaneHCID 707414-BromobenzaldehydeHCID 517165Ammonium Acetate

生成物 1

HCID 688204trans-4-Bromo-beta-nitrostyrene収率 83.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4-bromobenzaldehyde (16.8 g, 91 mmol), nitromethane (24.6 mL, 455 mmol), ammonium acetate (14 g, 182 mmol), and acetic acid (160 mL) was stirred for 4 hours at 100° C. This mixture was cooled to room temperature and poured into water. The precipitate thus produced was collected, washed with water, and dried under a reduced pressure to obtain the title compound (17.4 g). The title compound was used in the following reaction without any further purification.

後処理

  1. temperatureThis mixture was cooled to room temperature
  2. customThe precipitate thus produced
  3. customwas collected
  4. washwashed with water
  5. customdried under a reduced pressure

出典と根拠

ORDレコード
ord-047d50064f2148ab898bc3dc70987e87
出典データセット
uspto-grants-2014_09
特許番号
US08841327B2

関連ノート

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