関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 反応物 | Ethyl 3-(4-nitrophenoxy)benzoate | HCID 11323654 | — |
| 反応物 | Oxolane--water (1/1) | HCID 21881883 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-(4-Nitrophenoxy)benzoic acid | HCID 767919 | 95% |
反応手順
To a vigorously stirred mixture of 4-(3-ethoxycarbonylphenoxy)-1-nitrobenzene (5.14 g, 17.9 mmol) in a 3:1 THF/water solution (75 mL) was added a solution LiOH.H2O (1.50 g, 35.8 mmol) in water (36 mL). The resulting mixture was heated at 50° C. overnight, then cooled to room temp., concentrated under reduced pressure, and adjusted to pH 2 with a 1M HCl solution. The resulting bright yellow solids were removed by filtration and washed with hexane to give 4-(3-carboxyphenoxy)-1-nitrobenzene (4.40 g, 95%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08841330B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-7d682fa717ad412f9b24c6d02ddba9c3 |
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| 出典メモ | uspto-grants-2014_09 |
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