化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 4-bromo-3-(trifluoromethyl)aniline HCl salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Bromo-3-(trifluoromethyl)aniline | HCID 67852 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-bromo-3-(trifluoromethyl)aniline HCl salt | HCID 66745707 | 98% |
反応手順
To a solution of 4-bromo-3-(trifluoromethyl)aniline (64 g, 267 mmol) in Et2O (500 mL) was added an HCl solution (1 M in Et2O; 300 mL) dropwise and the resulting mixture was stirred at room temp. for 16 h. The resulting pink-white precipitate was removed by filtration and washed with Et2O (50 mL) and to afford 4-bromo-3-(trifluoromethyl)aniline HCl salt (73 g, 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841330B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-e7dd352353774123b85fa211e6af2f99 |
| 出典メモ | uspto-grants-2014_09 |