4-Aminophenol → 4-Chloro-N-methylpicolinamide

HRID 78344

反応式

HRID 78344 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][CH3:11])=[O:9])[CH:3]=1.[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1>CC(N(C)C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([NH:10][CH3:11])=[O:9])[CH:3]=1.[CH3:11][NH:10][C:8]([C:4]1[CH:3]=[C:2]([O:19][C:16]2[CH:17]=[CH:18][C:13]([NH2:12])=[CH:14][CH:15]=2)[CH:7]=[CH:6][N:5]=1)=[O:9]

参加物

5

反応物 2

HCID 4034-AminophenolHCID 14768144-Chloro-N-methylpicolinamide

生成物 2

HCID 14768144-Chloro-N-methylpicolinamideHCID 166551294-(4-Aminophenoxy)-N-methylpicolinamide

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

Entry 13: 4-Chloro-N-methyl-2-pyridinecarboxamide was synthesized according to Method A2, Step 3b. 4-Chloro-N-methyl-2-pyridinecarboxamide was reacted with 4-aminophenol according to Method A2, Step 4 using DMAC in place of DMF to give 4-(2-(N-methylcarbamoyl)-4-pyridyloxy)aniline. According to Method C2a, 2-methoxy-5-(trifluoromethyl)aniline was reacted with CDI followed by 4-(2-(N-methylcarbamoyl)-4-pyridyloxy)aniline to afford the urea.

出典と根拠

ORDレコード
ord-ed396393bf1745368e5bad38161b2326
出典データセット
uspto-grants-2014_09
特許番号
US08841330B2

関連ノート

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