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4-Aminophenol → 4-(4-Aminophenoxy)pyridine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminophenol | HCID 403 | — |
| 反応物 | 4-Chloropyridine-2-carboxamide | HCID 303543 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | 4-(4-Aminophenoxy)pyridine-2-carboxamide | HCID 23088338 | — |
反応手順
Entry 14: 4-Chloropyridine-2-carbonyl chloride HCl salt was reacted with ammonia according to Method A2, Step 3b to form 4-chloro-2-pyridinecarboxamide. 4-Chloro-2-pyridinecarboxamide was reacted with 4-aminophenol according to Method A2, Step 4 using DMAC in place of DMF to give 4-(2-carbamoyl-4-pyridyloxy)aniline. According to Method C4, 2-methoxy-5-(trifluoromethyl)aniline was reacted with phosgene followed by 4-(2-carbamoyl-4-pyridyloxy)aniline to afford the urea.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841330B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-cf231f4cc8884ff9a82ecbbbc11fd404 |
| 出典メモ | uspto-grants-2014_09 |