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4-Aminophenol → 4-(4-aminophenoxy)-N,N-dimethylpyridine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Aminophenol | HCID 403 | — |
| 反応物 | Dimethylamine | HCID 674 | — |
| 反応物 | 4-chloro-N,N-dimethylpyridine-2-carboxamide | HCID 4962252 | — |
| 反応物 | 4-chloropyridine-2-carbonyl Chloride | HCID 11095146 | — |
| 生成物 | 4-(4-aminophenoxy)-N,N-dimethylpyridine-2-carboxamide | HCID 23614563 | — |
反応手順
Entry 24: 4-Chloropyridine-2-carbonyl chloride was reacted with dimethylamine according to Method A2, Step 3b. The resulting 4-chloro-N,N-dimethyl-2-pyridinecarboxamide was reacted with 4-aminophenol according to Method A2, Step 4 to give 4-(2-(N,N-dimethylcarbamoyl)-4-pyridyloxy)aniline. 5-(Trifluoromethyl)-2-methoxyaniline was converted into 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method B1. 5-(Trifluoromethyl)-2-methoxyphenyl isocyanate was reacted with 4-(2-(N,N-dimethylcarbamoyl)-4-pyridyloxy)aniline according to Method C1a to afford the urea.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841330B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-c7777d915bf7437ea24abc648698258a |
| 出典メモ | uspto-grants-2014_09 |