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2-Methoxy-5-(trifluoromethyl)aniline → 3-(4-Aminophenoxy)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxy-5-(trifluoromethyl)aniline | HCID 600637 | — |
| 反応物 | Benzene, 2-isocyanato-1-methoxy-4-(trifluoromethyl)- | HCID 11983909 | — |
| 反応物 | 3-(4-Aminophenoxy)benzoic acid | HCID 23009036 | — |
| 生成物 | 3-(4-Aminophenoxy)benzoic acid | HCID 23009036 | — |
| 生成物 | N-(5-(trifluoromethyl)-2-methoxyphenyl)-N'-(3-carboxyphenyl)urea | HCID 23614600 | — |
反応手順
Entry 36: 4-(3-Carboxyphenoxy)aniline was synthesized according to Method A11. 5-(Trifluoromethyl)-2-methoxyaniline was converted into 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method B1. 4-(3-Carboxyphenoxy)aniline was reacted with 5-(trifluoromethyl)-2-methoxyphenyl isocyanate according to Method C1f to afford N-(5-(trifluoromethyl)-2-methoxyphenyl)-N′-(3-carboxyphenyl)urea, which was coupled with 4-fluoroaniline according to Method D1c.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841330B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-0d6d3c89f2ae44549d4065be26aaac3e |
| 出典メモ | uspto-grants-2014_09 |