Potassium Carbonate → 1-(4-Vinylbenzyl)-1,4,8,11-tetraazacyclotetradecane

反応式

[NH:1]1[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9][NH:8][CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:15](=O)([O-])[O-].[K+].[K+].ClC[CH:23]=[CH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>CN(C=O)C>[CH:24]([C:25]1[CH:26]=[CH:27][C:28]([CH2:15][N:1]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9][NH:8][CH2:7][CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[CH:29][CH:30]=1)=[CH2:23]

参加物

実験手順

40 g of cyclam (1) (200 mmol) are dissolved in 1 L of DMF at 70° C. 25 g (181 mmol) of potassium carbonate are added to the solution. A solution of 5.9 g (38.7 mmol) of chloromethylstyrene in 500 ml of DMF is added by slow dropwise addition (9 hours) with stirring. The reaction medium is stirred at 70° C. for an additional hour. After returning to ambient temperature, the excess cyclam and potassium carbonate is removed by filtration. The filtrate is evaporated and the residue is then taken up in diethyl ether. After evaporating the solvent, the compound is obtained in the form of a light yellow oil (11.2 g; 35.4 mmol). Yield: 91%.