Hydrochloric Acid → 2-(2-Methoxyethoxy)benzoic acid

HRID 78405ノート

反応式

HRID 78405 の反応式
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH2:11][CH2:12][O:13][CH3:14].Cl>[OH-].[K+].O>[CH3:14][O:13][CH2:12][CH2:11][O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[C:3]([OH:15])=[O:2]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 22381872Methyl 2-(2-methoxyethoxy)benzoate

生成物 1

HCID 134171032-(2-Methoxyethoxy)benzoic acid収率 98%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 14797Potassium Hydroxide溶媒

実験手順

A mixture of the product of Example 25A (0.27 g, 1.3 mmol) in 40% aqueous potassium hydroxide was stirred for 6 hours. The mixture was then diluted with water, made slightly acidic by the addition of 2 N aqueous HCl, and then extracted three times with ethyl acetate. The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 0.25 g of the title compound.

後処理

  1. extractionextracted three times with ethyl acetate
  2. dry with materialThe combined organic extracts were dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-e3e7113642bb4c3cb746faec7297c14e
出典データセット
uspto-grants-2014_09
特許番号
US08841334B2

反応ノート

読み込み中…