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1-Hydroxybenzotriazole → 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (4-methyl-5-morpholin-4-yl-thiazol-2-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 反応物 | 2,2,3,3-Tetramethylcyclopropanecarboxylic acid | HCID 152115 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 4-Methyl-5-morpholin-4-yl-thiazol-2-ylamine | HCID 86618905 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (4-methyl-5-morpholin-4-yl-thiazol-2-yl)-amide | HCID 86618904 | — |
反応手順
A mixture of 4-methyl-5-morpholin-4-yl-thiazol-2-ylamine (prepared using the method described in Christopher et al., Bioorganic and Medicinal Chemistry Letters 2004, 14(22), 5521-5525), N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, triethylamine, and 2,2,3,3-tetramethylcyclopropanecarboxylic acid were processed using the method described in Example 58 to afford the title compound. MS (ESI) m/z 324 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841334B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-36a87c5f875f426fa49b4967c0c7dab9 |
| 出典メモ | uspto-grants-2014_09 |