関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Propargyl bromide | HCID 7842 | — |
| 反応物 | 2-Amino-4,5-dimethyl-1,3-thiazole | HCID 73238 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4,5-dimethyl-3-(prop-2-ynyl)thiazol-2(3H)-imine hydrobromide | HCID 86640857 | 72.6% |
反応手順
To a solution of 4,5-dimethylthiazol-2-amine (2.5 g, 19.5 mmol) in 10 mL toluene was added propargyl bromide (2.78 g, 23.4 mmol). The reaction was heated at 85° C. for 12 h then cooled. The crude material was diluted with diethyl ether and the solid was collected via filtration to give 3.5 g of the title compound which was used without further purification. m/z 167.1 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08841334B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
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| ORD ID | ord-b6f5b5843ebb4d588a2e5b6422eff13e |
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| 出典メモ | uspto-grants-2014_09 |
|---|
