化工社化工社 化学情報印刷レポート · 研究参考用
N-bromobutanimide → Methyl 3-Amino-6-bromopyrazine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | Methyl 3-aminopyrazinecarboxylate | HCID 72669 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Methyl 3-Amino-6-bromopyrazine-2-carboxylate | HCID 227251 | 92.3% |
反応手順
A mixture of methyl 3-aminopyrazine-2-carboxylate (8.35 g, 54.53 mmol) and N-bromo-succinimide (9.705 g, 54.53 mmol) was stirred in MeCN (100 mL) at room temp overnight. The resultant precipitate was filtered, washed with MeCN and dried to give the desired product as a yellow solid (11.68 g, 92% Yield)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841308B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-12edde3285584efcae9147bf026fb43f |
| 出典メモ | uspto-grants-2014_09 |