Water → 1-(2-Isocyanobenzyl)-3-methylurea

HRID 78684ノート

反応式

HRID 78684 の反応式
Cl.C([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])#N.[CH3:12][N:13]=[C:14]=[O:15].[CH2:16]([N:18](CC)CC)C.O>ClCCl>[N+:18]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH:7][C:14]([NH:13][CH3:12])=[O:15])#[C-:16]

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 247216502-(Aminomethyl)benzonitrile hydrochloride

生成物 1

HCID 580761271-(2-Isocyanobenzyl)-3-methylurea収率 85%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2-cyanobenzylamine hydrochloride (90 g) and Dichloromethane (800 ml) were taken into a round bottomed (RB) flask. Methyl isocyanate (45.6 g) was added at 5° C. Triethylamine (81 g) in Dichloromethane (300 ml) was added at the same temperature and stirred at room temperature for 16 h. Water (1 L) was added and stirred for 30 min. The obtained solid was collected by filtration and dried in oven at 50° C. for 12 h. The yield is 85% and the purity 99.8%.

後処理

  1. stirringstirred for 30 min
  2. filtrationThe obtained solid was collected by filtration
  3. customdried in oven at 50° C. for 12 h

出典と根拠

ORDレコード
ord-d44dadcd95f54f90bf9533bb53ff1bad
出典データセット
uspto-grants-2014_09
特許番号
US08841447B2

反応ノート

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