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N-Acetylserotonin → 3-[2-(acetylamino)ethyl]-1H-indol-5-yl 4-nitrophenyl carbonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Acetylserotonin | HCID 903 | — |
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-[2-(acetylamino)ethyl]-1H-indol-5-yl 4-nitrophenyl carbonate | HCID 86712985 | 60% |
反応手順
To N-acetylserotonin (0.9 g; 4 mmol) was added N-methylmorpholine (0.92 ml, 8 mmol), and 4-nitrophenyl chloroformate (1.61 g; 8 mmol) dissolved in tetrahydrofuran. Reaction was carried out for 0.5 h under an argon atmosphere. The solvent was evaporated. The residue was purified by column chromatography (SiO2, methanol/methylene chloride) to give 0.92 g (yield 60%) of crystalline yellow product with a melting point 153-156° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841453B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-cb0d748909484c0fa6ac05719d52db41 |
| 出典メモ | uspto-grants-2014_09 |