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4-Iodo-o-toluidine → 2-Chloro-3-(2-fluoro-4-iodophenylamino)-isonicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Iodo-o-toluidine | HCID 83221 | — |
| 反応物 | 3-Chloro-2-fluoropyridine-4-carboxylic acid | HCID 12175428 | — |
| 反応物 | 3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid | HCID 59026791 | — |
| 生成物 | 2-Chloro-3-(2-fluoro-4-iodophenylamino)-isonicotinic acid | HCID 57649634 | — |
反応手順
2-Chloro-3-(2-fluoro-4-iodo-phenylamino)-isonicotinic acid was synthesized as outlined in General Method 1 and according to the procedure for the synthesis of intermediate 1 by reacting 4 mmol of 2-methyl-4-iodoaniline with 6 mmol 2-fluoro-3-chloro-isonicotinic acid. LC/MS [10.25 min; 390.9 (M−1)-ESI-].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841459B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-711002fca8c649d4bb18a7cce41ecffc |
| 出典メモ | uspto-grants-2014_09 |