Methanesulfonyl chloride → Methanesulfonic acid cis-2-benzhydryl-tetrahydropyran-4-ylester

反応式

[CH:1]([C@H:14]1[CH2:19][C@H:18]([OH:20])[CH2:17][CH2:16][O:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>>[CH:1]([C@H:14]1[CH2:19][C@@H:18]([O:20][S:22]([CH3:21])(=[O:24])=[O:23])[CH2:17][CH2:16][O:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

反応物 2

HCID 31297Methanesulfonyl chloride

HCID 66631792trans-2-Benzhydryl-tetrahydropyran-4-ol

生成物 1

HCID 86605344Methanesulfonic acid cis-2-benzhydryl-tetrahydropyran-4-ylester収率 98%

実験手順

Cis-2-diphenylmethyl-4-hydroxy-pyran 3b (0.3 g, 1.12 mmol) was reacted with methanesulfonyl chloride (0.26 g, 2.24 mmol) (Procedure A) to give compound 4b (0.38 g, 98%) as an oil.

出典と根拠

ORDレコード: ord-96a833ce7b40416fbec25721b1c14af9
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08841464B2

反応ノート

読み込み中…