Benzene → 2-benzhydryl-3,4-dihydro-2H-pyran

HRID 78895

反応式

HRID 78895 の反応式
C1([CH:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:8]([O:13][CH:14]=C)[CH2:9][CH2:10][CH:11]=C)C=CC=CC=1.[CH:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>Cl[Ru](=CC1C=CC=CC=1)([P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)([P](C1CCCCC1)(C1CCCCC1)C1CCCCC1)Cl>[CH:7]([CH:8]1[CH2:9][CH2:10][CH:11]=[CH:14][O:13]1)([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

4

反応物 2

HCID 241BenzeneHCID 666312581,1-Diphenyl-2-(1-ethenoxy)-hex-5-ene

生成物 1

HCID 666312272-benzhydryl-3,4-dihydro-2H-pyran収率 92.6%

試薬・触媒・溶媒 1

HCID 178479819HCID 178479819、化合物触媒

実験手順

A solution of 1,1-diphenyl-2-(1-ethenoxy)-hex-5-ene 9 (5.1 g, 18.3 mmol) and Grubb's catalyst (1.5 g, 1.83 mmol) in benzene (200 ml) was heated under reflux for 20 hr. The solvent was removed under vacuo and the residue was chromatographed over silica gel (Hexane/Ethyl Acetate 20:1) to give 2-diphenyl-3,4-dihydro-2H-pyran 10 (4.25 g, 92.6%) as a liquid.

後処理

  1. temperatureunder reflux for 20 hr
  2. customThe solvent was removed under vacuo
  3. customthe residue was chromatographed over silica gel (Hexane/Ethyl Acetate 20:1)

出典と根拠

ORDレコード
ord-610562bf6af8475e806557347a3cbda5
出典データセット
uspto-grants-2014_09
特許番号
US08841464B2

関連ノート

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