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Acetic Acid → Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(3,4-dichloro-benzyl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 3,4-Dichlorobenzaldehyde | HCID 22710 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine | HCID 11565229 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(3,4-dichloro-benzyl)-amine | HCID 66631954 | 75% |
反応手順
Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.1 g, 0.38 mmol) was reacted with 3,4-dichlorobenzaldehyde (0.066 g, 0.38 mmol) in the presence of glacial acetic acid (0.023 g, 0.38 mmol) in 1,2-dichloroethane (20 ml), and NaCNBH3 (0.03 g, 0.45 mmol) in methanol (5 ml) (Procedure D) to give compound 16i (0.12 g, 75%) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841464B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-8db3f1b5281c4a639784b668402d90ef |
| 出典メモ | uspto-grants-2014_09 |