Hydrochloric Acid → 1-(3-Chloro-5-fluoro-4-methoxyphenyl)-1-hexanone

HRID 7894

反応式

HRID 7894 の反応式
[Cl-].[Al+3].[Cl-].[Cl-].[Cl:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[C:7]=1[O:13][CH3:14].[C:15](Cl)(=[O:21])[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].Cl>>[Cl:5][C:6]1[CH:11]=[C:10]([C:15](=[O:21])[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH:9]=[C:8]([F:12])[C:7]=1[O:13][CH3:14]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 67340Hexanoyl chlorideHCID 27735812-Chloro-6-fluoroanisoleHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 219909381-(3-Chloro-5-fluoro-4-methoxyphenyl)-1-hexanone

実験手順

Aluminum chloride (1.16 g, 8.72 mmol) was added to a stirred mixture of 1-chloro-3-fluoro-2-methoxybenzene (1.00 mL, 8.72 mmol) and hexanoyl chloride (1.47 mL, 10.46 mmol) at room temperature. The mixture warmed and HCl evolution occurred. The resulting mixture was stirred at room temperature for 67 hours and then partitioned between EtOAc (40 mL) and ice cold water (40 mL). The EtOAc layer was washed with brine (30 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield crude 1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone as an oil.

後処理

  1. temperatureThe mixture warmed
  2. custompartitioned between EtOAc (40 mL) and ice cold water (40 mL)
  3. washThe EtOAc layer was washed with brine (30 mL)
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customevaporated under vacuum

出典と根拠

ORDレコード
ord-ec39dbd4e6074985880755ae6356933c
出典データセット
uspto-grants-2006_08
特許番号
US07087599B2

関連ノート

読み込み中…