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Benzenesulfonamide, 3-amino- → N-(3-sulfamoylphenyl)-4-(trifluoromethoxy)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenesulfonamide, 3-amino- | HCID 7377 | — |
| 反応物 | 4-(Trifluoromethoxy)benzoyl Chloride | HCID 142110 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | N-(3-sulfamoylphenyl)-4-(trifluoromethoxy)benzamide | HCID 4784511 | — |
反応手順
To a solution of 3-amino-benzenesulfonamide (17 mg, 0.10 mmol) in pyridine (1 mL) was added 4-trifluoromethoxy benzoyl chloride (16 μL, 0.10 mmol). The reaction was stirred at room temperature for 15 h and purified by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give N-(3-(aminosulfonyl)phenyl)-4-(trifluoromethoxy)benzamide. LC/MS: m/z 360.9 (M+H)+ at 3.02 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841483B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-0ad32f6959f3494a890a8ff7c4c23a47 |
| 出典メモ | uspto-grants-2014_09 |