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Benzenesulfonamide, 3-amino- → 2-cyclohexyl-N-(3-(aminosulfonyl)phenyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenesulfonamide, 3-amino- | HCID 7377 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-cyclohexylbenzoic Acid | HCID 7020572 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-cyclohexyl-N-(3-(aminosulfonyl)phenyl)benzamide | HCID 24855264 | — |
反応手順
A solution of 2-cyclohexyl benzoic acid (20 mg, 0.10 mmol) and HATU (38 mg, 0.10 mmol) in DMF (1 mL) was stirred at room temperature 3 min. To this solution was added 3-amino-benzenesulfonamide (17 mg, 0.10 mmol) and triethylamine (14 μL, 0.10 mmol). The reaction was stirred at room temperature for 16 h and purified by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give 2-cyclohexyl-N-(3-(aminosulfonyl)phenyl)benzamide. LC/MS: m/z 359.1 (M+H)+ at 3.85 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841483B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7c0b71d177244859a5b82e65e13df75e |
| 出典メモ | uspto-grants-2014_09 |