関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cyclopropanemethanamine | HCID 75646 | — |
| 反応物 | 2-Amino-4-chloropyrimidine | HCID 223332 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N4-(cyclopropylmethyl)pyrimidine-2,4-diamine | HCID 20277654 | — |
反応手順
To cyclopropylmethanamine (3.62 g, 50.9 mmol) in ethanol (90 mL) was added solid 4-chloropyrimidin-2-amine (6.00 g, 46.3 mmol). The reaction was stirred at reflux (100° C. oil bath) for 16 h. The reaction was cooled to room temperature and solvent was removed in vacuo. The product 237 obtained in quantitative yield. LCMS-ESI (POS), M/Z, M+1: Found 165.0, Calculated 165.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08841312B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-26b22e2f8cc54faebcb8ade065724197 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
