Cyclopropanemethanamine → N4-(cyclopropylmethyl)pyrimidine-2,4-diamine

HRID 79145

反応式

HRID 79145 の反応式
[CH:1]1([CH2:4][NH2:5])[CH2:3][CH2:2]1.Cl[C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[N:8]=1>C(O)C>[CH:1]1([CH2:4][NH:5][C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[N:8]=2)[CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 75646CyclopropanemethanamineHCID 2233322-Amino-4-chloropyrimidine

生成物 1

HCID 20277654N4-(cyclopropylmethyl)pyrimidine-2,4-diamine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
100 °C

実験手順

To cyclopropylmethanamine (3.62 g, 50.9 mmol) in ethanol (90 mL) was added solid 4-chloropyrimidin-2-amine (6.00 g, 46.3 mmol). The reaction was stirred at reflux (100° C. oil bath) for 16 h. The reaction was cooled to room temperature and solvent was removed in vacuo. The product 237 obtained in quantitative yield. LCMS-ESI (POS), M/Z, M+1: Found 165.0, Calculated 165.1.

後処理

  1. temperatureThe reaction was cooled to room temperature
  2. customsolvent was removed in vacuo

出典と根拠

ORDレコード
ord-26b22e2f8cc54faebcb8ade065724197
出典データセット
uspto-grants-2014_09
特許番号
US08841312B2

関連ノート

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