Carbon tetrabromide → 2-(Bromomethyl)-6-methoxypyridine
反応式
[CH3:1][O:2][C:3]1[N:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][CH:4]=1.[Br:11]C(Br)(Br)Br.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[Br:11][CH2:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=1参加物
5
実験手順
To (6-methoxypyridin-2-yl)methanol (3.36 g, 24.1 mmol) in DCM (30 mL) was added perbromomethane (12.0 g, 36.2 mmol) and triphenylphosphine (9.50 g, 36.2 mmol). The reaction mixture was stirred for 1 hour, concentrated and silica gel chromatography (EtOAc/Hexane 1:5) to provide the desired product (4.23 g).
後処理
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-329eca199b4c468c9768351cf32f991a
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841455B2
反応ノート
読み込み中…