Phosphorus sulfide (P2S5) → N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(1,3,4-thiadiazol-2-yl)imidazo[1,2-a]pyridine-3-carboxamide

関与物質

反応条件

反応手順

To N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(2-formylhydrazinecarbonyl)imidazo[1,2-a]pyridine-3-carboxamide (36 mg, 0.073 mmol) in toluene/dioxane (1 mL/1 mL) was added hexamethyldisiloxane (71 mg, 0.44 mmol) and P2S5 (81 mg, 0.36 mmol). The reaction mixture was sealed and heated in a microwave reactor to 110° C. for 3 hours. The mixture was then concentrated under reduced pressure and the residue was purified by silica gel chromatography (DCM/MeOH 10:1) to provide the final product (1.5 mg). MS (ES+APCI) m/z=495 (M+H).

情報源と証拠