Carbon tetrabromide → 2-(Bromomethyl)-6-methylpyridine
反応式
[CH3:1][C:2]1[N:7]=[C:6]([CH2:8]O)[CH:5]=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:30]>ClCCl>[Br:30][CH2:8][C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=1参加物
5
実験手順
To an ice cooled a solution of (6-methylpyridin-2-yl)methanol (400 mg, 3.25 mmol) in dichloromethane (16 mL) under an atmosphere of dry nitrogen was added triphenylphosphine (1278 mg, 4.87 mmol) and carbon tetrabromide (1616 mg, 4.87 mmol). The mixture was stirred for 1 hour. The solvent was removed under reduced pressure and the residue was purified by chromatography on silica, eluting with 2-4% methanol in dichloromethane to give 2-(bromomethyl)-6-methylpyridine as an oil (402 mg).
後処理
- customThe solvent was removed under reduced pressure
- customthe residue was purified by chromatography on silica
- washeluting with 2-4% methanol in dichloromethane
出典と根拠
- ORDレコード
- ord-d5b7f4e6014b4c3e92fe9055a43e9c05
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841455B2
反応ノート
読み込み中…