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Thionyl Chloride → 3-(chloromethyl)-1,5-dimethyl-1H-pyrazole hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (1,5-Dimethyl-1H-Pyrazol-3-Yl)Methanol | HCID 2776366 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(chloromethyl)-1,5-dimethyl-1H-pyrazole hydrochloride | HCID 66937557 | 101.8% |
反応手順
To (1,5-dimethyl-1H-pyrazol-3-yl)methanol (5.01 g, 39.71 mmol) in DCM (80 mL) at 0° C. was cautiously added thionyl chloride (25 mL, 343.6 mmol). The cold bath was removed and the reaction mixture was stirred at ambient temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to give crude product (7.32 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841455B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-a0e28097d0434a88bd9c842f43cfe4a0 |
| 出典メモ | uspto-grants-2014_09 |