Thionyl Chloride → HCID 66937557、化合物

HRID 79370

反応式

HRID 79370 の反応式
[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][C:4]([CH2:8]O)=[N:3]1.S(Cl)([Cl:12])=O>C(Cl)Cl>[ClH:12].[Cl:12][CH2:8][C:4]1[CH:5]=[C:6]([CH3:7])[N:2]([CH3:1])[N:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 2776366(1,5-Dimethyl-1H-Pyrazol-3-Yl)Methanol

生成物 1

HCID 66937557HCID 66937557、化合物収率 101.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To (1,5-dimethyl-1H-pyrazol-3-yl)methanol (5.01 g, 39.71 mmol) in DCM (80 mL) at 0° C. was cautiously added thionyl chloride (25 mL, 343.6 mmol). The cold bath was removed and the reaction mixture was stirred at ambient temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to give crude product (7.32 g).

後処理

  1. customat 0° C.
  2. customThe cold bath was removed
  3. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a0e28097d0434a88bd9c842f43cfe4a0
出典データセット
uspto-grants-2014_09
特許番号
US08841455B2

関連ノート

読み込み中…