Solketal → (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl methanesulfonate
反応式
[CH3:1][C:2]1([CH3:9])[O:6][CH:5]([CH2:7][OH:8])[CH2:4][O:3]1.[CH3:10][S:11](Cl)(=[O:13])=[O:12].C(N(CC)CC)C>C(Cl)Cl>[CH3:10][S:11]([O:8][CH2:7][CH:5]1[CH2:4][O:3][C:2]([CH3:9])([CH3:1])[O:6]1)(=[O:13])=[O:12]参加物
5
実験手順
To (2,2-dimethyl-1,3-dioxolan-4-yl)methanol (400 mg, 3.03 mmol) in DCM (6 mL) at 0° C. was added methanesulfonyl chloride (381 mg, 3.33 mmol) and triethylamine (368 mg, 3.63 mmol. The cold bath was removed and the reaction mixture was stirred for 30 minutes. The mixture was diluted with DCM (5 mL). The organic phase was washed with water (4 mL) and brine (2 mL), and dried (Na2SO4). The solution was concentrated under reduced pressure to give the product (642 mg).
後処理
- customThe cold bath was removed
- additionThe mixture was diluted with DCM (5 mL)
- washThe organic phase was washed with water (4 mL) and brine (2 mL)
- dry with materialdried (Na2SO4)
- concentrationThe solution was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-c6973e2a5d534758b3d1c9b5b6305e53
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08841455B2
反応ノート
読み込み中…